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Isorhamnetin: A review of pharmacological effects
Aug 01, 2020 · Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the effects of cardiovascular and cerebrovascular protection, anti-tumor, anti …
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0000750686-17-000191.txt : 20170928 0000750686-17-000191.hdr.sgml : 20170928 20170928083631 accession number: 0000750686-17-000191 conformed submission type: 8-k public document count: 29 conformed period of report: 20170928 item information: regulation fd disclosure item information: financial statements and exhibits filed as of date: 20170928 date …
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Mutation Clusters from Cancer Exome. - Abstract
Aug 15, 2017 · On the other hand, the dominant part of CSig2 (C > T mutations in TCA, TCC, TCG, TCT) is subsumed in Cluster Cl-10 (see Figure 10), and the dominant part of CSig13 (C > G mutations in TCA, TCC, TCT) is subsumed in Cluster Cl-9 (see Figure 9). Basically, it appears that the large (each with 16 mutation categories) Clusters Cl-9, Cl-10 and Cl-11 ...
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Mechanically activated ion channel Piezo1 modulates
May 31, 2021 · Samples were derived from the same experiment and the resulting blots were processed in parallel. b, c Representative Western ... 177, and 191 cells ... I. D. C. NF-κB signaling in macrophages ...
Comorbidities of COPD | European Respiratory Society
By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly …
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GÎLCĂ, D. BREBEANU, Roxana STĂNESCU, E. ŢICĂU, C. DUBIŢ - Investigation of the effect of risk elements in bulls and dairy cows breeding around of the industrial area of Bucharest ½ Investigaţii privind efectul elementelor de risc la taurinele la îngrăşat şi vacile de lapte crescute in jurul zonei industriale a municipiului ...
OX40L blockade protects against inflammation-driven
Jul 05, 2016 · Fibrosis is a leading cause of death in industrialized countries. Until now, there has been no effective therapy to prevent or counteract the fibrotic process. This article describes the effect of the blockade of a late costimulatory molecule to prevent inflammation-driven skin, lung, and vessel fibrosis and to induce regression of established dermal fibrosis in vivo in …
COMPOSITIONS AND METHODS FOR PERSONALIZED
Stringent temperature conditions will ordinarily include temperatures of at least about 30° C., more preferably of at least about 37° C., and most preferably of at least about 42° C. Varying additional parameters, such as hybridization time, the concentration of detergent, e.g., sodium dodecyl sulfate (SDS), and the inclusion or exclusion of ...
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Macrophage plasticity and polarization: in vivo veritas
HIF-1α activities (25). IL-4 also induces c-Myc activity in human macrophages (26), which controls genes of M2 activation (Scarb1, Alox15, and Mrc1) as well as STAT6 and PPARγ activation (26). TLR engagement leads to NF-κB activation and production of
Cellular and molecular mechanisms breaking immune
Apr 01, 2021 · Lee, C. E. et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. Blood 124 , 2964–2972 (2014).
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IκBα is required for full transcriptional induction of
Dec 01, 2021 · Interestingly, among the ERGs recapitulated with model v4, there were well-known NFκB pathway regulators 40,41 (e.g., A20) and TFs (e.g., JUNB and KLF10), which are key inflammation and breast ...
Transcription Factor NRF2 as a Therapeutic Target for
Systems medicine has a mechanism-based rather than a symptom- or organ-based approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this work, we apply this to transcription factor nuclear factor (erythroid-derived 2)–like 2 (NRF2) by cross-validating its position in a protein–protein interaction network (the NRF2 interactome) …
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Hepatitis B Virus Protein X-induced Expression of the CXC
Interferon-γ inducible protein 10 (IP-10) involves inflammatory cell recruitment and cellular immune damage during virus infection. Although an increase of the peripheral IP-10 level is known in HBV-infected patients, the molecular basis of HBV infection inducing IP-10 expression has remained elusive. In the present study, we demonstrate that hepatitis B virus protein X …