IκBα is required for full transcriptional induction of
Dec 01, 2021 · Interestingly, among the ERGs recapitulated with model v4, there were well-known NFκB pathway regulators 40,41 (e.g., A20) and TFs (e.g., JUNB and KLF10), which are key inflammation and breast ...
Curcumin: a modulator of inflammatory signaling pathways
May 28, 2019 · Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been …
NLRP3 Inflammasome: A Promising Therapeutic Target for
NLRP3 inflammasome priming and activation. The priming (left) is provided by activation of pathogen-associated molecular patterns (PAMPs) or cytokines, leading to the transcriptional upregulation of NLRP3, IL-1, and IL-18 in a NF-κB-dependent way. Those genes' transcriptions are induced through the recognition of engage pattern-recognition receptors.
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Cold atom clocks and their applications in precision
Jan 01, 2021 · Cold atom clocks have made remarkable progresses in the last two decades and played critical roles in precision measurements. Primary Cs fountain frequency standards have achieved a total uncertainty of a few parts in 10 16, and the best optical clock has reached a type B uncertainty below 10 −18.Besides applications in the metrology, navigation, etc., ultra-stable …
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Cell type-dependent control of NF-Y activity by TGF-β
Jan 23, 2006 · Transforming growth factor β (TGF-β) is a pluripotent cytokine that regulates cell growth and differentiation in a cell type-dependent fashion. TGF …
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Global characterization of macrophage polarization
Nov 02, 2021 · He et al. provide a detailed characterization of dynamic temporal changes in cell signaling and metabolism during macrophage polarization by using quantitative time-course proteomics and phosphoproteomics and identify pharmacologic inhibitors of M2-type macrophage polarization. These data uncover a critical role of MEK/ERK signaling for …
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Mechanically activated ion channel Piezo1 modulates
May 31, 2021 · Samples were derived from the same experiment and the resulting blots were processed in parallel. b, c Representative Western ... 177, and 191 cells ... I. D. C. NF-κB signaling in macrophages ...
Hepatitis B Virus Protein X-induced Expression of the CXC
Interferon-γ inducible protein 10 (IP-10) involves inflammatory cell recruitment and cellular immune damage during virus infection. Although an increase of the peripheral IP-10 level is known in HBV-infected patients, the molecular basis of HBV infection inducing IP-10 expression has remained elusive. In the present study, we demonstrate that hepatitis B virus protein X …
Induction of IL19 expression through JNK and cGAS-STING
Dec 21, 2021 · Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and cGAS-STING and that IL19 expression was required for the …
Chapter 21: RLC Circuits
PHY2054: Chapter 21 19 Power in AC Circuits ÎPower formula ÎRewrite using Îcosφis the “power factor” To maximize power delivered to circuit ⇒make φclose to zero Max power delivered to load happens at resonance E.g., too much inductive reactance (X L) can be cancelled by increasing X C (e.g., circuits with large motors) 2 P ave rms=IR rms ave rms rms rms cos
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Mutation Clusters from Cancer Exome. - Abstract
Aug 15, 2017 · On the other hand, the dominant part of CSig2 (C > T mutations in TCA, TCC, TCG, TCT) is subsumed in Cluster Cl-10 (see Figure 10), and the dominant part of CSig13 (C > G mutations in TCA, TCC, TCT) is subsumed in Cluster Cl-9 (see Figure 9). Basically, it appears that the large (each with 16 mutation categories) Clusters Cl-9, Cl-10 and Cl-11 ...
Macrophage plasticity and polarization: in vivo veritas
HIF-1α activities (25). IL-4 also induces c-Myc activity in human macrophages (26), which controls genes of M2 activation (Scarb1, Alox15, and Mrc1) as well as STAT6 and PPARγ activation (26). TLR engagement leads to NF-κB activation and production of
OX40L blockade protects against inflammation-driven
Jul 05, 2016 · Fibrosis is a leading cause of death in industrialized countries. Until now, there has been no effective therapy to prevent or counteract the fibrotic process. This article describes the effect of the blockade of a late costimulatory molecule to prevent inflammation-driven skin, lung, and vessel fibrosis and to induce regression of established dermal fibrosis in vivo in …
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NAD+ in aging, metabolism, and neurodegeneration
Jan 06, 2016 · Nicotinamide adenine dinucleotide (NAD +) is a key cellular factor for intermediary metabolism. Originally defined as a molecular fraction (“cozymase”) that accelerated fermentation in yeast extracts, its chemical structure was resolved as a nucleotide sugar phosphate. The nicotinamide portion of NAD + is the site of reduction-oxidation ...
COMPOSITIONS AND METHODS FOR PERSONALIZED
Stringent temperature conditions will ordinarily include temperatures of at least about 30° C., more preferably of at least about 37° C., and most preferably of at least about 42° C. Varying additional parameters, such as hybridization time, the concentration of detergent, e.g., sodium dodecyl sulfate (SDS), and the inclusion or exclusion of ...
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Graphene materials in green energy applications: Recent
Mar 01, 2020 · Graphene, composed of single-layered sp 2 graphite, with its superb physical and chemical properties, has attracted scientists in different areas, including electronics, medicine, and chemicals. Its applications in green energy were extensively studied in the past two decades. Results from different studies show that graphene-based products with different structures (2D …
SAP table column FIELDNAME (ERP EHP7 6.0 schema) definitions
SAP table definition for column alias FIELDNAME - schema ERP EHP7 6.0
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